Hey guys ! Welcome back and today I will be sharing information about one the emerging technologies that is Organs-on-chip.
An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems, a type of artificial organ.Organs_on_chip are Microchips lined by living human cells that could revolutionize drug development, disease modeling and personalized medicine.
Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to model human diseases in vitro in order to accelerate the development of new drugs and advance personalized medicine.
With their ability to host and combine the different cell and tissue types making up human organs, organs-on-chips present an ideal microenvironment to mimic human-specific pathophysiologies and enable molecular and cellular scale analysis and identification of new therapeutic targets within an organ-level context in vitro. They even allow recreating therapeutically relevant interfaces like the blood-brain-barrier to facilitate discovery of new drug delivery platforms or culturing living microbiome for extended times in direct contact with living human intestinal cells to enable insights into how these microbes influence health and disease.
Hope this post would have helped you understand what organs-on-chip actually isand what are its benefits.